PiaSky® (crovalimab) Dosing & Administration

Treatment on your patients’ terms: PiaSky® can be taken at home once every 4 weeks1-3

The initial PiaSky® loading dose is one IV infusion, administered by a healthcare provider. The next 4 loading doses are subcutaneous injections, given once per week. Maintenance doses are then administered once every 4 weeks subcutaneously, with no further IV infusions required. Patients can self-inject PiaSky® after the initial loading dose and after receiving training from their healthcare provider.

PiaSky® offers your patients a different way to administer their treatment, by allowing subcutaneous self-injections outside of a healthcare setting.

Product photo
PiaSky dosing schedule showing an initial IV infusion, followed by weekly subcutaneous injections, then ongoing maintenance injections every four weeks.

Administer PiaSky® doses based on body weight3

Body Weight

40 kg to <100 kg

≥100 kg

Loading Dose

Day 1

1000 mg (IV)

1500 mg (IV)

Day 2, 8, 15, 22

340 mg (SC)

340 mg (SC)

Maintenance Dose

Day 29 and Q4W thereafter

680 mg (SC)

1020 mg (SC)

Dosing & Administration

Patients can self-inject their PiaSky® maintenance doses subcutaneously within minutes, once prepared³˒⁴

How to train your patients or their caregivers to prepare and administer subcutaneous injections for PiaSky®

The initial PiaSky® loading dose is an IV infusion, administered by a healthcare provider.1

 

PiaSky® is prepared and administered in a series of simple steps5

Preparing the injection
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
1. Check the vial(s)
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
2. Warm up time
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
3. Collect the other supplies
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
4. Wash your hands before filling the syringe
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
5. Clean the vial top
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
6. Attach the transfer needle
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
7. Fill the syringe with air
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
8. Uncap the transfer needle
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
9. Inject air into the vial
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
10. Transfer all the medicine
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
11. Remove the air bubbles
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
12. Recap the transfer needle
Step-by-step visual guide for preparing PiaSky® for subcutaneous injection, including checking the vial, warming the medicine, cleaning the vial top, filling the syringe, removing air bubbles, and safely attaching and recapping the transfer needle.
13. Remove the transfer needle

Administering PiaSky®
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
1. Choose the injection site
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
2. Clean the injection site
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
3. Attach the injection needle
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
4. Uncap the injection needle
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
5. Adjust the plunger
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
6. Insert the needle
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
7. Inject the medicine
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
8. Cover the injection needle
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
9. Dispose of the syringe and vial
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.
10. Check the injection site
Step-by-step guide for administering PiaSky® subcutaneous injections, showing how to choose and clean the injection site, attach and insert the needle, inject the medicine, cover the site, and safely dispose of the syringe and vial.

How do you ensure that patients are properly trained for subcutaneous self-administration of PiaSky?
syringe-pink

By training your patients to self-administer their PiaSky® injections, you may help empower them to take treatment into their hands.³˒⁶*

*Patients starting PiaSky® will receive an initial weight-based loading dose through IV infusion. Four subsequent loading doses are then given weekly by subcutaneous injection. Weight-based maintenance dosing is then administered once every 4 weeks subcutaneously. Patients may self-inject after receiving training from their healthcare provider.
IV = intravenous; Q4W = 4-weekly; SC = subcutaneous.
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Why PiaSky®

A C5 inhibitor in a subcutaneous injection can help give PNH patients their lives back.

See How
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PiaSky® Efficacy

Learn more about results with PiaSky® in treatment-naïve and switch trials.

See The Data
References
  1. Röth A, et al. Am J Hematol. 2024;99:1768–1777.
  2. Scheinberg P, et al. Am J Hematol. 2024;99:1757–1767.
  3. PiaSky® (crovalimab) 170mg/mL solution for injection Summary of Product Characteristics. F. Hoffmann-La Roche; 2024.
  4. Rӧth A, et al. Blood. 2020;135:912–920.
  5. PiaSky® (crovalimab) 170mg/mL solution for injection Package Leaflet. F. Hoffmann-La Roche; 2024.
  6. Overton P, et al. Patient Prefer Adherence 2021:15:811–834.